NGI affiliated lab includes any faculty using high-throughput omic data to understand the pathobiology of human with focus on leverage human samples to study neurodegenerative diseases. There is no cost to join, but there are many benefits to becoming an NGI Center Affiliated lab member.

Isabel Alfradique-Dunham

Sees patients for Parkinson’s disease and atypical Parkinsonism, tremor, Huntington’s disease, dystonia, botulinum toxin, deep brain stimulation (DBS).

Andrew Aschenbrenner

Evaluating the utility of intraindividual variability in cognition and personality as predictors of AD risk, applying novel statistical techniques (e.g., dynamic structural equation modeling) and computational models to further understand cognitive changes in the earliest stages of AD.

Mikhail Berezin

The Berezin Lab searches for optical signatures of biological tissue using hyperspectral imaging from ultraviolet (UV) to shortwave infrared (SWIR), designs optically active probes to understand chemotherapy-induced peripheral neuropathy (CIPN) in vivo, and develops novel optical instrumentation for spectroscopy and imaging. Our research interest lies in the investigation and application of molecular excited states — the cornerstone of a variety of chemical, physical and biological phenomena.

David Brogan

Dedicated to conducting brachial plexus and peripheral nerve research that is directly relevant to patients, clinicians, scientists, and policy-makers. The lab has 2 components: (1) Epidemiologic, economic, and clinical analysis of brachial plexus injuries and (2) Translational nerve research.

Alex Chamessian

Gereau Lab utilizes a combination of behavioral studies, patch clamp electrophysiology, optogenetics, in vivo imaging, molecular and genetic approaches to understand the signaling pathways involved in nervous system plasticity that underlies pain sensitization. Their mission is to identify novel approaches to reverse this maladaptive plasticity to provide new therapeutic strategies to reduce pain and its impact on patient quality of life.

Sharlee Climer

Primary research interest is the development of combinatorial methods for biological applications. A key focus is to identify patterns in genetic data, such as the one shown at the top of this webpage, and determine associations of these patterns with traits of interest, such as Alzheimer disease.

Jonathan Cooper

For the last 20 years, work in Jonathan Cooper’s Pediatric Storage Disorders Laboratory (PSDL) has focused upon investigating the pathogenesis of the neuronal ceroid lipofuscinoses (NCLs, or Batten disease), and other similar neurodegenerative lysosomal storage disorders. They have unbiased stereology to characterize multiple mouse and larger animal models NCL, and have used this information in order to be able to target a range of different pre-clinical interventions to where they can be most effective. This work has led to several clinical trials and an approved treatment for CLN2 disease

Joseph Corbo

A major effort of Corbo lab is directed toward understanding the transcriptional regulatory networks that orchestrate the development and function of photoreceptors. They are employing a wide range of experimental and computational techniques to decipher these networks. Recently, they generated comprehensive maps of rod- and cone-specific open chromatin using ATAC-seq and have leveraged these maps to elucidate the differences in cis-regulatory grammar between these two cell types. They are now using a massively parallel reporter assay called CRE-seq to further interrogate the architecture of photoreceptor cis-regulatory elements. Our ultimate goal is to create a complete, quantitative model of photoreceptor transcriptional regulation including a detailed cis-regulatory grammar. This model will serve as a template for translating between both coding and non-coding variants and the complex cellular phenotypes of photoreceptors that result in blindness.

Patricia Dickson

The Dickson laboratory studies the mucopolysaccharidosis (MPS) disorders, which are lysosomal enzyme deficiencies affecting the catabolism of glycosaminoglycans. Central nervous system manifestations include progressive intellectual disability, communicating hydrocephalus, dysmyelination, spinal cord compression, and cortical atrophy. Our lab studies cerebrospinal fluid delivery of recombinant enzymes to treat central nervous disease due to MPS, and has demonstrated biodistribution of intrathecally-delivered recombinant enzymes throughout the neuroaxis of MPS models, with correction of lysosomal storage. The laboratory also studies neuroimaging and neuropathology of white matter in MPS brain and the humoral immune responses to therapeutic enzymes. Projects range from bench to bedside including clinical trials.

Christopher Dy

Dedicated to conducting brachial plexus and peripheral nerve research that is directly relevant to patients, clinicians, scientists, and policy-makers. The lab has 2 components: (1) Epidemiologic, economic, and clinical analysis of brachial plexus injuries and (2) Translational nerve research.

Nelly Friedrichsen

The Benzinger Lab uses novel position emission tomography (PET) and magnetic resonance imaging (MRI) images to investigate biomarkers in aging and neurodegenerative diseases very early.

Robert Gereau

Gereau Lab utilizes a combination of behavioral studies, patch clamp electrophysiology, optogenetics, in vivo imaging, molecular and genetic approaches to understand the signaling pathways involved in nervous system plasticity that underlies pain sensitization. Their mission is to identify novel approaches to reverse this maladaptive plasticity to provide new therapeutic strategies to reduce pain and its impact on patient quality of life.

James Giles

Research is focused on GWAS, Single Cell RNA-seq/ATAC, Spacial transcriptomics, Epigenetics, Proteomics.

Brian Gordon 

The Gordon Neuroimaging Lab focuses on understanding the complexities of the aging brain. This includes studies of both healthy aging as well as neurodegenerative diseases such as Alzheimer disease. We integrate cognitive testing alongside advanced neuroimaging techniques, including MRI (volumetric, DTI, and fMRI) and PET imaging (amyloid, tau, and FDG). Our research crosses multiple domains and is at the intersection of cognitive neuroscience, psychology, neurology and radiology

Peter Jin

Formation, development, and application of genetic, genomic and bioinformatic methods to better anlayze and integrate exome and genome sequencing, SNP array, RNA-sequencing ,epigenmoic, metabolomic and protemomic data 

Celeste Karch

The goal of the Karch lab is to understand the molecular mechanisms that drive neurodegenerative diseases using functional genomic and stem cell approaches. Dr. Karch has built a somatic and stem cell collection containing a series of deeply clinically characterized cell lines from individuals carrying genetic drivers of Alzheimer’s disease, frontotemporal dementia, amyotrophic lateral sclerosis and Parkinson’s disease

Fuhai Li 

Applying statistical, machine learning, deep learning and data mining approaches on diverse biomedical dataset integration and interpretation, to solve the challenges in bioinformatics, system biology, and image informatics

Jorge Llibre-Guerra

Epidemiological studies show a rapid increase in dementia in Hispanic populations. However, there is little understanding of disease onset, progression, and biomarker trajectories in Latino populations. Jorge’s aims to understand genetic versus social determinants that drive Alzheimer’s disease in Latino populations

Shamim A Mollah

Mollah Lab is focused on developing computational approaches to address critical challenges in Systems Medicine where we apply network-based models on multi-omics data to understand complex diseases at the systems level. We are particularly interested in exploring the ways in which genomic / proteomic technologies coupled with computational approaches drawn from AI, machine learning, graph theory, linear algebra, and operation research can transform cancer research, leading to new biological insights and revolutionizing clinical practice. 

Ginger Nicol

Improving health outcomes and supporting weight management in adults ages 18-65 who are currently taking antipsychotic medication.

Chia-Ling Phuah

Understanding the pathophysiology of cerebrovascular disease by leveraging big data approaches in combining genetic, clinical, and neuroimaging data, with the overarching goal of deriving clinical relevant information to drive innovations in treatment strategies, and improve precision in clinical decision-making and risk stratification. data: 

Marco Sardiello

Medical Genetics is the main focus of Sardiello lab. Working on the foundation that the Human Genome Project has built, they are constantly trying to characterize un-annotated genes and proteins that are associated with hereditary disorders.

Aristeidis Sotiras

Medical Imaging and Data Science (MINDS) Lab, led by Aristeidis Sotiras, PhD, is powered by a team of researchers developing unique computer algorithms and machine learning techniques to better understand brain development, brain aging, and brain tumor segmentation

Fumihiko Urano

The goal of Urano laboratory is to reveal the molecular mechanisms of Wolfram syndrome and develop patient-based therapeutics for this complex disorder using genetic information from each patient and patient-derived induced pluripotent stem cells (iPSCs)

Ananth Vellimana

Treats Brain aneurysms, Arteriovenous malformations (AVM), Cavernous malformations (cavernoma), Dural arteriovenous fistulas, Spinal vascular malformations, Ischemic stroke, carotid stenosis  (carotid endarterectomy, angioplasty/stenting), intracranial stenosis, Moyamoya disease, bypass surgery, Open, endoscopic and radiosurgical treatment of skull base tumors including Pituitary tumors, Meningomas, Acoustic neuromas, Chordomas, Chondrosarcomas, Sinonasal tumors, Microvascular or macrovascular decompression and radiosurgery for trigeminal neuralgia, hemifacial spasm, glossopharyngeal neuralgia, Idiopathic intracranial hypertension (shunt, venous sinus stenting), Jugular venous compression syndrome, Intracranial hypotension/CSF-venous fistula, Intraarterial chemotherapy.

Andrew Yoo

Yoo Lab studies the role of microRNAs and chromatin remodeling complexes in neurogenesis and devise cellular reprogramming approaches to generate human neurons by directly converting skin fibroblasts to neurons. Their goal is to model adult-onset neurodegenerative disorders with patient-derived neurons and study how aging of human neurons contributes to the vulnerability to neurodegeneration data. 

Dmitriy Yablonskiy

Dmitriy A. Yablonskiy, PhD, is a professor of radiology and a principal investigator in the Biomedical MR Center for Mallinckrodt Institute of Radiology at Washington University School of Medicine in St. Louis. Yablonskiy’s work focuses on revealing new biophysical mechanisms underlying MRI signal and using these mechanisms for developing new MRI-based techniques to study biological tissue structure and functioning. Since entering the MRI field, Yablonskiy has authored and co-authored more than 100 peer-review papers in the areas of MRI and physiology that are highly cited.

Some of the Yablonskiy Lab’s major achievements include the development of gradient echo plural contrast imaging (GEPCI) and its advance version the genetically-informed quantitative gradient recalled echo (qGRE), in vivo lung morphometry with hyperpolarized 3He MRI, and quantitative BOLD (qBOLD). Yablonskiy has also developed quantitative methods of diffusion MRI, MRI spectroscopy, lipid quantitation in fatty livers, and biophysical theory of brain temperature regulation. These new methods provide safe and non-invasive in vivo biomarkers for monitoring progression of different diseases, thus opening doors to substantially improve diagnostics and perform fast and accurate longitudinal studies for clinical monitoring and research trials.

Recent work is focused on applying MRI-based GEPCI and qGRE techniques to link brain genetic and cellular microstructure with brain functioning in healthy people and patients with brain diseases, including Alzheimer’s disease, multiple sclerosis and amyotrophic lateral sclerosis.

Abhirami Kannan Iyer

Abhi is an Instructor in Dept. of Psychiatry in Dr. Celeste Karch’s laboratory in the Department of Psychiatry. During her PhD, Abhi elucidated the regulatory role of cytokine signaling pathways in the function of lipid antigen presenting molecule CD1d and restricted innate lymphocytes, Natural Killer T (NKT) cells. For her postdoctoral work, Abhi chose to work in neuroimmunology, whereby her initial work was focused at understanding mechanisms involved in CD4+ T cell-mediated motor neuron survival in peripheral nerve injury and amyotrophic lateral sclerosis (ALS). Thereafter, Abhi carried out preclinical testing of antisense oligonucleotides against α2-Na+/K+ ATPase, which is upregulated in astrocytes and contributes to non-cell autonomous neurodegeneration in ALS. Her current work aims to understand TREM2 signaling in neurodegenerative diseases in human induced pluripotent stem cell (iPSC)-differentiated microglial cells. She has experience in different forms of scientific writing including grants, manuscripts, review articles and is an ad-hoc reviewer for multiple journals.

Anne Cross

The goal of our research is to understand the mechanisms involved in pathogenesis of inflammation and demyelination in the central nervous system (CNS-brain and spinal cord). Our studies utilize detailed and quantitative imaging of human CNS, with cutting edge techniques developed at this institution. Other studies employ animal models for the human disease multiple sclerosis (MS), such as experimental autoimmune encephalomyelitis (EAE) and cuprizone toxicity models. Together with the laboratory of Hope Center member Dr. Laura Piccio, we study the effects of adipokines (cytokines derived from adipose tissue) in animal models of MS. We are currently funded to a) use an imaging method called Gradient Echo Plural Contrast imaging in a longitudinal study of patients with different subtypes of MS, b) use diffusion imaging to study MS brains and spinal cords, and c) to perform an open-label study of every-other-day fasting in MS patients undergoing relapse.

Claudia Han

Our interest lies in elucidating the function of various brain macrophages in neuropathology and the molecular mechanisms driving these phenotypes. We utilize a variety of techniques including genomics, stem cell modeling and genetic mouse models. 

Gabor Egervari

I am interested in exploring the emerging interface between cellular metabolism and epigenetic mechanisms. Recent evidence suggests that transcriptional regulation is tightly linked with intermediary metabolism via the availability of substrates and co-factors for epigenetic enzymes. In addition, metabolic enzymes are recruited to the nucleus and chromatin to control local levels of specific metabolites. I am particularly interested in the role of the epigenetic-metabolic axis in the brain during learning and memory, with emphasis on alcohol use disorder and Alzheimer’s disease.

Ganesh Chand

Biomedical Imaging, neurophysics, neuroengineering, neuroinformatics, computational neuroscience, neuroimaging, neurophysiology, clinical research, machine learning, artificial intelligence, big data

Guoyan Zhao

We integrate multiple cutting-edge computational and experimental approaches to study gene transcriptional regulation in the nervous system and  how changes in the regulation contribute to neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson disease (PD) and Lewy body diseases (LBDs).

Hong Chen

I’m the director of the Chen Ultrasound Laboratory at Washington University in St. Louis. Our research laboratory combines engineering, biology, and medicine to develop ultrasound techniques for noninvasive, targeted, and personalized brain cancer treatment and for understanding the brain function. For more information about our lab, please visit

Wei Feng

Wei Feng, M.D., is a board certified endocrinologist with expertise in many areas such as diabetes, thyroid, pituitary, osteoporosis, PCOS, obesity, lipid disorder, and adrenal disease. She has been a staff physician at the Department of Diabetes, Endocrinology, and Metabolism at City of Hope since 1998. She joined the faculty of the Department of Endocrinology and Diabetes at City of Hope in 1998.

Born in China, Dr. Feng obtained her medical degree at University of Heidelberg in West Germany in 1987. After completing residency training in internal medicine at University of Memphis in Tennessee, she sought endocrine fellowship training at Cedars Sinai Medical Center. She has diverse clinical experience being hospitalist for a year in 1992 after completing residency training at Memphis Regional Medical Center and a faculty member in the Division of General Internal Medicine at USC between 1995 and 1998.

Dr. Feng has been a principal investigator for several clinical trials involving long term studies of intervention for high-risk diabetic patients to prevent cardiovascular events, treatment for diabetic peripheral neuropathy, islet cell transplant program, and new treatment options for type 1 and type 2 diabetes.

Elizabeth Pollina

Experienced Postdoctoral Fellow with a demonstrated history of working in the higher education industry. Skilled in Genomic Analysis, Flow Cytometry, Molecular Biology, Fluorescence Microscopy, Mouse Genetics, and Cell Biology. PhD focused in Cancer Biology from Stanford University and Postdoctoral Experience in Molecular and Cellular Neuroscience.