The Neurogenomics and Informatics Center, Washington University School of Medicine, in collaboration with the GSK Genetics Therapy Area is recruiting a Postdoctoral Research Scientists. Our group generates and analyzes genetic and multi-tissue proteomic data from large and well characterized cohorts of Alzheimer disease cases and controls.

Proteomic and other omic data (transcriptomics, metabolomics and lipidomics) will be used to perform QTL mapping, colocalization and Mendelian Randomization to identify novel causal genes, proteins and pathways for Alzheimer disease risk, onset and progression, as well as to create new prediction models and identify druggable targets.

We are seeking highly motivated researchers with strong analytical skills, especially in quantitative human genetics and Mendelian Randomization to lead the analyses for these projects. The new postdoc(s) will join a large team, currently 30+ members, which is led by three faculty members, four postdocs, several PhD students, and three senior scientists.

A successful applicant will have:

  • A PhD in Genetics, Bioinformatics, Computer Science, Data Science, Statistical Genomics, or a related discipline involving the interrogation of ‘omics’ datasets, or expect to obtain a degree in the near future,
  • Hands-on experience on GWAS analyses (PLINK, METAL), colocalization (COLOC, mashr, SMR)   Mendelian Randomization (TwoSamplesMR, MR-EGGER, MR-PRESSO) and omic data processing
  • Solid skills in at least one programming language (R, python, or perl) and experience working in Linux and/or high-performance cluster environments,
  • A strong ability to perform analytical reasoning to extract biological insights from data-driven approaches,
  • Familiarity with interrogation of publicly available resources.

Job Location

This position is a collaboration between the Cruchaga lab and GSK.  This position will be located at Dr. Cruchaga lab on the NeuroGenomics and Informatics Center (Department of Psychiatry) at Washington University, but there will be regular interactions with the GSK team including some short internships at GSK labs.


This position is eligible for full-time benefits.  Please click the following link to view a summary of benefits:

Applicant Instructions

Interested candidates should send their cover letter and CV to

EOE Statement

The Washington University School of Medicine is renowned for its research cohorts of neurodegenerative disorders, which include clinical, neuroimaging, and fluid biomarker phenotypes.  Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.