Publications

Leveraging IPS-derived neurons and brain tissue to identify novel genes implicated on Frontotemporal Dementia

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R406W causes a specific form of frontotemporal dementia. We found that GABAergic dysfunction in postmortem tissue from people with sporadic FTD or progressive supranuclear palsy, but not in Alzheimer’s disease.

 

Also highlighted in Alzforum:

https://www.alzforum.org/news/research-news/stem-cell-model-nails-link-between-tauopathy-and-gabaergic-dysfunction

 

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