We are always looking for creative, enthusiastic, and productive people who would like to work in an exciting, highly collaborative research environment.

Open Positions

Postdoctoral Position in Alzheimer Disease: Multi-omics

Description

The NeuroGenetics and Informatics (NGI) group (https://neurogenomics.wustl.edu/) at Washington University School of Medicine is recruiting multiple Postdoctoral Research Scientists. The NGI generates and analyzes Whole-Genome Sequencing data and high-throughput multi-dimensional omic data to study neurodegeneration and diseases of the central nervous system with emphasis on Alzheimer’s disease, Parkinson’s disease, and other dementias. The ultimate goal of the NGI is to understand the biology of these diseases, to define novel biomarkers, and to identify novel therapeutical targets. Washington University School of Medicine is renowned for its research cohorts of neurodegenerative disorders, which include clinical, neuroimaging, and fluid biomarker phenotypes.

We have pioneered the use of Whole Exome and Whole Genome sequencing data in familial (Cruchaga et al., Nature 2013., Fernandez et al., Eur J HumGenet 2016, Fernandez et al., PLoS Genetics 2017, Fernandez et al., Front Neuroscience 2018) and sporadic (Jin et al., Alzheimer Res Ther 2012, Benitez et al., PLoS Genetics, 2013, Benitez et al., N Engl J Med 2013 Jin SC Human Mol Genet 2014) Alzheimer disease to identify novel variants and genes associated with disease risk.

We have recently received several NIH R01 awards to generated and analyze large WGS dataset for both familial Alzheimer Disease and sporadic early-onset cases. We are seeking highly motivated researchers with strong analytical skills, especially in genetics and WGS/WES analyses to lead the analyses for these projects. The new postdoc(s) will join a large team, currently twenty members, which is led by three faculty members, four postdocs, several PhD students and three senior scientists.

For further details please see our website: https://neurogenomics.wustl.edu/.

Required Qualifications

  • The successful applicant will hold, or shortly expects to obtain, a PhD qualification in Genetics, Bioinformatics, Computer Science, Data Science, Statistical Genomics or a related discipline involving the interrogation of ‘omics’ datasets. 
  • Hands-on experience with large-scale human genomic (PLINK, SKAT, BWA, GATK) or other omics (preferably related to neurodegeneration) studies is expected.
  • Solid skills in at least one programming language (R, python or perl) and experience working in Linux and/or high-performance cluster environments.
  • A strong ability to perform analytical reasoning to extract biological insights from data-driven approaches will be critical.
  • Familiarity to interrogate publicly available resources will be highly beneficial.

Department Name/Job Location

This position is the NeuroGenomics and Informatics group (Department of Psychiatry) at Washington University.

Benefits

This position is eligible for full-time benefits.  Please click the following link to view a summary of benefits: https://hr.wustl.edu/benefits/.

Applicant Special Instructions

Interested candidates should send their cover letter and CV to Dr. Cruchaga (cruchagac@wustl.edu )

EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Postdoctoral Position in Alzheimer Disease: Brain Single Nuclei

Description

The Harari Lab at the Neurogenetics and Informatics (NGI) Center is offering Postdoctoral Research Scientist positions in the department of Psychiatry at Washington university in St. Louis. We generate and analyze high-throughput multi-omic data to study neurodegeneration and diseases of the central nervous system with emphasis on Alzheimer’s disease, Parkinson’s disease, and other dementias. Our ultimate goal of the NGI is to understand the biology of these diseases, to define novel biomarkers, and to identify novel therapeutical targets. Washington University School of Medicine is renowned for its research cohorts of neurodegenerative disorders, which include clinical, neuroimaging, and fluid biomarker phenotypes.

We are currently employing deep molecular profiling of brain, using single-nuclei RNA-seq to characterize a large collection of samples.  We are seeking for entrepreneurial, motivated researcher with strong analytical skills to join our effort and generate novel insights of neurodegeneration with this unique dataset, while working in a highly dynamic multidisciplinary and collaborative environment.

Dr. Harari is well funded with several grants from the National Institute of Ageing, CZI and Archer Fund.

Requirements

The successful applicant will hold, or shortly expects to obtain, a PhD qualification in Genetics, Bioinformatics, Computer science, Data science, Statistical Genomics  or a related discipline involving the interrogation of ‘omics’ datasets.  A hands-on experience with large-scale human genomic or other omics, preferably related to human single-cell RNA-seq using Seurat or ScanPy packages, is expected. He/she would have solid skills in at least one programming language (R, python or perl) and experience working in Linux and/or high-performance cluster environments. A strong ability to perform analytical reasoning to extract biological insights from data-driven approaches will be critical. In addition, familiarity to interrogate publicly available resources will be highly beneficial.

 

 

Applicant Instructions

Interested candidates should send their cover letter and CV to Dr. Harari (harario@wustl.edu )

 

Postdoctoral Position in Parkinson Disease multi-omics and genomics

A postdoctoral research associate position is immediately available in the Benitez Lab at the newly created NeuroGenomics and Informatics (NGI) center (https://neurogenomics.wustl.edu/), in the Department of Psychiatry at Washington University in St. Louis. The role would involve conducting and leading analyses of high-throughput multi-omic data in samples from Parkinson’s disease patients with in-depth phenotyping data, including clinical, neuroimaging, and fluid biomarker phenotypes. We are particularly interested in applicants with a strong background in data-driven approaches using genomic and multi-omic methods, who enjoy quantitative analysis and are motivated to deeply understand the underlying mechanism of neurodegenerative diseases like Parkinson’s disease. The research will be focused on integrating genomic data and plasma, cerebrospinal fluid, and brain proteomic analysis using Mendelian Randomization. The position will provide extensive opportunities for leadership, growth, and innovation.

Qualifications

  • Ph.D. in computer science, bioinformatics, mathematics, statistics, or related field
  • Excellent team communication skills and ability to collaborate with a team working on bioinformatics, statistical genomics, and genetics.
  • Demonstrated expertise in data science, including a track record of peer-reviewed publications and/or published software as the first author
  • Fluency with the molecular biology omics stack with experience in the neurogenetic field
  • Experience analyzing data from next-gen genomics methods, such as (but not limited to) genome-wide sequencing and proteomic profiling
  • Experience with systems biology discovery methods including differential expression, gene network discovery, pathway enrichment analysis, Mendelian Randomization.
  • Experience with data analysis in Python or R, in a Linux/Unix in a cloud-based environment
  • Familiarity with code repositories, such as Github
  • Desire to work in a fast-paced academic environment

Benefits

This position is eligible for full-time benefits.

Information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs.

Applicant Special Instructions

To apply for this position, please send a cover letter, CV, and contact information for three references to Bruno Benitez babenitez@wustl.edu

Our laboratories are a part of the Department of Psychiatry at Washington University in St Louis, an institution at the forefront of neurogenetics research embedded in the vibrant and livable city of St. Louis. Our institution is characterized by outstanding research support facilities in various domains and a hard-working yet friendly and collaborative scientific culture.

Diversity and Inclusion are core values at Washington University. Washington University seeks an exceptionally qualified and diverse faculty, staff, students, and postdocs; women, minorities, protected veterans, and candidates with disabilities are strongly encouraged to apply.

Senior Scientist: Brain Multi-omics

The Harari Lab at the Neurogenetics and Informatics (NGI) Center in the department of Psychiatry at Washington university in St. Louis is looking for a Senior Scientist. We analyze high-throughput multi-omic data to study neurodegeneration and diseases of the central nervous system with emphasis on Alzheimer’s disease, Parkinson’s disease, and other dementias. Our ultimate goal of the NGI is to understand the biology of these diseases, to define novel biomarkers, and to identify novel therapeutical targets. Washington University School of Medicine is renowned for its research cohorts of neurodegenerative disorders, which include clinical, neuroimaging, and fluid biomarker phenotypes.

We are currently employing deep molecular profiling of brain, using single-nuclei RNA-seq to characterize a large collection of samples.  We are seeking for entrepreneurial, motivated researcher with strong analytical skills to join our effort and generate novel insights of neurodegeneration with this unique dataset, while working in a highly dynamic multidisciplinary and collaborative environment.

PRIMARY DUTIES AND RESPONSIBILITIES:

  1. Collaborates with PI on the design, conduct and reporting of research projects.
  2. Assists with grant preparation and reporting.
  3. Prepares and submits papers on research.
  4. Develops hypotheses to be tested and ways of testing it.
  5. To develop and maintain analytical pipelines for single-nuclei RNA-seq.
  6. Analyze data including QC, as well as perform analyses.
  7. Maintain an updated repository of data publicly available
  8. Manages staff scientist
  9. Coordinates research project with other institutions and investigators.
  10. Conducts literature searches related to research project

Applicant Instructions

Interested candidates should send their cover letter and CV to Dr. Harari (harario@wustl.edu )

Programmer

The NeuroGenetics and informatics (NGI) center (https://neurogenomics.wustl.edu/) at Washington University School of Medicine is looking for a Programmer to join our team.

We are seeking applicants for a Programmer position to create and maintain relational and non-relational databases for research projects, develop websites to share scientific data and analyses, and provide support for computing in cloud / cluster environments.

PRINCIPAL DUTIES & RESPONSIBILITIES:

Essential Functions:

  1. Collaborate on the design of SQL and NoSQL databases.
  2. Write and optimize SQL queries and reports
  3. Migrate and consolidate data from other systems
  4. Develop data acquisition processes from technical instruments
  5. Develop, deploy and maintain Web applications (Using R shiny or Python Web frameworks Django, TurboGears or web2py)
  6. Creating Docker containers
  7. Develop processing pipelines for cluster environments

CRITICAL SKILLS/EXPERTISE: The candidate will hold a bachelor’s degree in Computer Science, IT-related degree, Statistics, Bioinformatics, Biostatistics, Mathematics or similar.

The candidate should have a background in programing SQL queries, and python/R (ideally developing Web applications using R Shiny), Unix (bash scripts), working knowledge of Python (using any Web application framework) HTML, CSS and JavaScript. Ideally he/she should have experience coding in FileMakerPro and NoSQL queries  and should be familiar with Agile methodologies. In addition, it would be ideal to have wxperience computing in cluster environments (Portable Batch System/ Load Sharing Facility), cloud computing (AWS), sysadmin experience (linux), and Familiarity with docker (Dockerfile authoring, detached execution),

Applicant Instructions

Interested candidates should send their cover letter and CV to Dr. Harari (harario@wustl.edu )

Data Scientist: Parkinson Disease

The Benitez lab seeks a Bioinformatician, Data Scientist or Computational Biologist to join the Parkinson’s team research group in the newly created NeuroGenomics and Informatics (NGI) Center (https://neurogenomics.wustl.edu) at Washington University School of Medicine. The lab’s ultimate goal is to understand Parkinson’s diseases’ biology, define novel genes, pathways, biomarkers, and identify novel therapeutic targets.

This exciting opportunity will generate and analyze high-throughput multi-omic data in samples from Parkinson’s disease patients with deep phenotyping data, including clinical, neuroimaging, and fluid biomarker phenotypes using genomic and multi-omic approaches. The role will include integrating genomic data and plasma, cerebrospinal fluid, and brain proteomic analysis using Mendelian Randomization. This position will report directly to Dr. Benitez, the co-leader of the functional unit of the NGI. This project is well funded with grants from the National Institute of Neurological Disorders and stroke.

We seek a highly self-motivated applicant with a strong interest in identifying novel biomarkers and therapeutic targets for Parkinson’s Disease. Strong technical ability, with a background in statistics/mathematics/computer science. Experience with programming in a high-level language preferred (e.g., R, Perl, Python, Java, C, C++, etc.) and working in Linux/UNIX. Experience with high-performance compute clusters and/or cloud computing platforms. Ability to perform analytical reasoning to extract biological insights from data-driven approaches and assist in completing and interpreting uni- and multivariate statistical analysis. Hands-on experience with large-scale human genomic or other omics datasets is expected. Excellent team communication skills and ability to collaborate with a team working on bioinformatics, statistical genomics, and genetics.

Minimum qualifications Master’s degree in computer science, bioinformatics, biostatistics, or related field.

Preferred qualifications: Ph.D. in a data science-related field (Genetics, Health informatics, Computer science, Data Science, Statistical genomics)

Benefits

This position is eligible for full-time benefits.

Applicant Special Instructions

To apply for this position, please send a cover letter, CV, and contact information for three references to Bruno Benitez babenitez@wustl.edu

Our laboratories are a part of the Department of Psychiatry at Washington University in St Louis, an institution at the forefront of neurogenetics research embedded in the vibrant and livable city of St. Louis. Our institution is characterized by exceptional research support facilities in various domains and a hard-working yet friendly and collaborative scientific culture.

Diversity and Inclusion are core values at Washington University. Washington University seeks an exceptionally qualified and diverse faculty, staff, students and postdocs; women, minorities, protected veterans, and candidates with disabilities are strongly encouraged to apply.

Bioinformatician: WGS and GWAS

The NeuroGenetics and Informatics (NGI) group (https://neurogenomics.wustl.edu/) at Washington University School of Medicine is recruiting a Bioinformatics Research Analyst to work in Dr. Cruchaga lab at the Washington University School of Medicine. The NGI generates and analyzes Whole-Genome Sequencing data and high-throughput multi-dimensional omic data to study neurodegeneration and diseases of the central nervous system with emphasis on Alzheimer’s disease, Parkinson’s disease, and other dementias. The goal of our research is to use genomic and multi-omic approaches to understand the biology of Alzheimer’s Disease, Parkinson Disease and other neurodegenerative disease. Our labs have pioneered the use of biomarker levels for Alzheimer and Parkinson disease as endophenotypes for genetic studies.

We are looking for a Bioinformatics Research Analyst with expertise in GWAS, WES/WGS and/or RNA-seq data analyses to work in a project focus on the identification of genes dysregulated in Alzheimer disease.

She/he will join a team of nine computational and statistical researchers working in bioinformatics, statistical genomics and genetics. The team comprises over 20 people dedicated to understanding the architecture of neurodegenerative diseases.

Required Qualifications

The candidate will hold a master in statistics, Bioinformatics, Computational Biology, Biostatistics, Statistical Genetics, Medical Statistics, Mathematics or similar. The candidate should have a strong background in GWAS (PLINK and SKAT-O), and WES/WGS (BWA, GATK) or RNA-seq analyses (STAR, SALMON, KALLISTO, DESEQ2). A working knowledge of UNIX, Perl/Python, R and Docker are also required.

Department Name/Job Location

This position is the NeuroGenomics and Informatics group (Department of Psychiatry) at Washington University.

Benefits

This position is eligible for full-time benefits. Please click the following link to view a summary of benefits: https://hr.wustl.edu/benefits/.

Applicant Special Instructions

Interested candidates should send their cover letter and CV to Dr. Cruchaga (cruchagac@wustl.edu )

EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Bioinformatician: Single Nuclei RNA-Seq

The Harari Lab at the Neurogenetics and Informatics center (NGI) in the department of Psychiatry at Washington university in St. Louis Center is looking to Bioinformatician, Computational Biologist and Research Scientist to join our team. We generate and analyze high-throughput multi-omic data to study neurodegeneration and diseases of the central nervous system with emphasis on Alzheimer’s disease, Parkinson’s disease, and other dementias. Our ultimate goal of the NGI is to understand the biology of these diseases, to define novel biomarkers, and to identify novel therapeutical targets. Washington University School of Medicine is renowned for its research cohorts of neurodegenerative disorders, which include clinical, neuroimaging, and fluid biomarker phenotypes.

We are currently employing deep molecular profiling of brain, using single-nuclei RNA-seq to characterize a large collection of samples.  We are seeking for entrepreneurial, motivated researcher with strong analytical skills to join our effort and generate novel insights of neurodegeneration with this unique dataset, while working in a highly dynamic multidisciplinary and collaborative environment.

Requirements

The successful applicant will hold, Master Digree in qualification in Genetics, Bioinformatics, Computer science, Data science, Statistical Genomics or a related discipline involving the interrogation of ‘omics’ datasets.  A hands-on experience with large-scale human genomic or other omics studies is expected, preferably related to human single-cell RNA-seq using Seurat or ScanPy packages. He/she would have solid skills in at least one programming language (R, python or perl) and experience working in Linux and/or high-performance cluster environments. A strong ability to perform analytical reasoning to extract biological insights from data-driven approaches will be critical. In addition, familiarity to interrogate publicly available resources will be highly beneficial.

Diversity and Inclusion are core values at Washington University. Washington University seeks an exceptionally qualified and diverse faculty, staff, students and postdocs; women, minorities, protected veterans, and candidates with disabilities are strongly encouraged to apply.

Applicant Instructions

Interested candidates should send their cover letter and CV to Dr. Harari (harario@wustl.edu )

Fulfilled Positions

Project Manager

The goal of the Neurogenomics and Informatics group is a multidisciplinary team working at the forefront of personalized medicine. The goal of the NeuroGenomics and Informatics Group is to understand the biology of neurodegeneration by using high-dimensional omic data and functional genomic approaches. The Neurogenomics and Informatics group is looking for an experienced project manager to work directly with the center director. The project manager will be responsible for the oversight and administration of multiple research projects progress report and manuscript writing, and publication, coordination of the activities of a multidisciplinary team, or interfaces with multiple levels of the organization and external entities to ongoing and future projects

PRINCIPAL DUTIES & RESPONSIBILITIES:

Essential Functions:

  1. Holds responsibility for day-to-day activities of the Neurogenomics and Informatic center.
  2. Assists with drafting, writing, editing, and galley-proofing of progress report abstracts and article for publication
  1. Composes annual report for the center, maintain content for the center website and social media
  2. Supervises support staff and advises senior faculty in personnel management or internal policy.
  3. May prepare and maintain minutes from meetings, formal voting procedures, and committee activity related to proposals, ensuring follow up on decisions made.
  4. Provides planning and coordination of meetings and schedules various events and/or training.
  5. Establishes/enhances various contacts’, and contact with other centers and research groups to facilitate collaboration and exchange of information.
  6. Participates in project review meetings and report preparation and analysis.

CRITICAL SKILLS/EXPERTISE

  • Excellent administrative skills.
  • Experience with research required
  • Applicant should have significant experience with word processing, spreadsheets, graphics, and the applicant must have database and internet experience.
  • Excellent oral and written communication is required.
  • Applicant must be able to work independently and manage multiple assignments with various levels of priority.
  • Attention to detail and accuracy are essential

Department Name/Job Location

This position is the NeuroGenomics and Informatics group (Department of Psychiatry) at Washington University.

Benefits

This position is eligible for full-time benefits. Please click the following link to view a summary of benefits: https://hr.wustl.edu/benefits/.

Applicant Special Instructions

Interested candidates should send their cover letter and CV to Drs. Cruchaga (cruchagac@wustl.edu )

EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Research Laboratory Supervisor

The Neurogenomics and Informatics Center uses high throughput multi-omic approaches to understand the biology of neurodegeneration with emphasis in Alzheimer and Parkinson Disease. The Neurogenomics and Informatics Center a quickly growing group looking for an experienced laboratory supervisor that can work diligently in a team environment.

PRINCIPLE DUTIES & RESPONSIBILITIES:

Essential Functions:

  1. Performs laboratory administrative functions such as scheduling, purchasing and establishing record keeping systems.
  2. Supervises laboratory staff assigned, assuring appropriate study procedures, review of staff work, explaining policies and procedures and screening of new employees.
  3. Develops procedure manuals and operational/technical guidelines for lab studies.
  4. Participates in lab study processes, maintaining records and preparing reports as required.
  5. Researches and recommends new methods and procedures to maintain current capabilities, quality and standards following CAP and Part11 rules.

Department Name/Job Location

This position is the NeuroGenomics and Informatics group (Department of Psychiatry) at Washington University.

Benefits

This position is eligible for full-time benefits. Please click the following link to view a summary of benefits: https://hr.wustl.edu/benefits/.

Applicant Special Instructions

Interested candidates should send their cover letter and CV to Drs. Cruchaga (cruchagac@wustl.edu )

EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.