We are always looking for creative, enthusiastic, and productive people who would like to work in an exciting, highly collaborative research environment.

Postdoctoral Position in Alzheimer Disease Genetics and Genomics

Description

The NeuroGenetics and Informatics (NGI) group (https://neurogenomics.wustl.edu/) at Washington University School of Medicine is recruiting multiple Postdoctoral Research Scientists. The NGI generates and analyzes Whole-Genome Sequencing data and high-throughput multi-dimensional omic data to study neurodegeneration and diseases of the central nervous system with emphasis on Alzheimer’s disease, Parkinson’s disease, and other dementias. The ultimate goal of the NGI is to understand the biology of these diseases, to define novel biomarkers, and to identify novel therapeutical targets. Washington University School of Medicine is renowned for its research cohorts of neurodegenerative disorders, which include clinical, neuroimaging, and fluid biomarker phenotypes.

We have pioneered the use of Whole Exome and Whole Genome sequencing data in familial (Cruchaga et al., Nature 2013., Fernandez et al., Eur J HumGenet 2016, Fernandez et al., PLoS Genetics 2017, Fernandez et al., Front Neuroscience 2018) and sporadic (Jin et al., Alzheimer Res Ther 2012, Benitez et al., PLoS Genetics, 2013, Benitez et al., N Engl J Med 2013 Jin SC Human Mol Genet 2014) Alzheimer disease to identify novel variants and genes associated with disease risk.

We have recently received several NIH R01 awards to generated and analyze large WGS dataset for both familial Alzheimer Disease and sporadic early-onset cases. We are seeking highly motivated researchers with strong analytical skills, especially in genetics and WGS/WES analyses to lead the analyses for these projects. The new postdoc(s) will join a large team, currently twenty members, which is led by three faculty members, four postdocs, several PhD students and three senior scientists.

For further details please see our website: https://neurogenomics.wustl.edu/.

Required Qualifications

  • The successful applicant will hold, or shortly expects to obtain, a PhD qualification in Genetics, Bioinformatics, Computer Science, Data Science, Statistical Genomics or a related discipline involving the interrogation of ‘omics’ datasets. 
  • Hands-on experience with large-scale human genomic (PLINK, SKAT, BWA, GATK) or other omics (preferably related to neurodegeneration) studies is expected.
  • Solid skills in at least one programming language (R, python or perl) and experience working in Linux and/or high-performance cluster environments.
  • A strong ability to perform analytical reasoning to extract biological insights from data-driven approaches will be critical.
  • Familiarity to interrogate publicly available resources will be highly beneficial.

Department Name/Job Location

This position is the NeuroGenomics and Informatics group (Department of Psychiatry) at Washington University.

 

Benefits

This position is eligible for full-time benefits.  Please click the following link to view a summary of benefits: https://hr.wustl.edu/benefits/.

Applicant Special Instructions

Interested candidates should send their cover letter and CV to Drs. Cruchaga (cruchagac@wustl.edu )

EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

 

Postdoctoral Research Associate – Functional genomics for neurodegenerative diseases

A postdoctoral scholar position is available in the NeuroGenomics and Informatics (NGI) Group (https://neurogenomics.wustl.edu/), in the Department of Psychiatry at Washington University in St. Louis. This will be a position in the labs of Dr. Bruno Benitez and Dr. Carlos Cruchaga, both of whom have a research focus on the understanding of the genetic and pathophysiological mechanisms of neurodegenerative diseases. The role would involve conducting and leading functional experiments in cells to understand how specific mutations in several genes may cause neurodegenerative diseases such as Alzheimer’s or Parkinson’s disease. We are particularly interested in applicants with a strong background in cell biology/biochemistry, (experience working with stem cell culture (iPSC-derived neurons, microglia or astrocytes), site-directed mutagenesis, western blotting, cloning, lentivirus vectors as well as CRISPR/Cas9), who enjoy method development and are motivated to deeply understand the functional consequences of mutations from human patients. The research will be focused on a combination of molecular and biochemical studies utilizing primary cell lines and iPS cell, 1) develop the appropriate molecular tools to sub clone wild-type and mutants form of genes associated with neurodegenerative diseases, 2) define the molecular mechanisms altering protein levels for specific mutations, and 3) identify the effects of specific genes on essential neurodegenerative pathways.  The position will provide extensive opportunities for leadership, growth, and innovation.

 

The functional genomics unit of the NeuroGenomics and Informatics group utilizes a variety of techniques spanning from human molecular genetics, genomics and informatics to mouse models to understand how genetic mutations discovered in individuals with Alzheimer’s, Parkinson’s and related dementia’s lead to functional disruptions in cells and the brain. The collaboration between the Cruchaga, Harari, Karch and Benitez labs provides a great training environment for those interest in functional genomics. We are particularly known for discovering novel genes and variants associated with neurodegenerative diseases: We recently identified the MS4A cluster of genes affecting the cerebrospinal fluid (CSF) levels of soluble TREM2 (Sci Transl Med. 2019) and identified the GMNC gene as a genetic modifier of CSF tau levels (Neuron. 2013). In addition, we identified a protective variant in the TMEM106B gene that may have a neuronal protection effect against general aging (Acta Neuropathol. 2019).

 

Our laboratories are a part of the Department of Psychiatry at Washington University in St Louis – an institution at the forefront of neurogenetics research that is embedded in the vibrant and livable city of St. Louis. Our institution is characterized by phenomenal research support facilities in a variety of domains and a hard-working yet friendly and collaborative scientific culture.

 

Required Qualifications

Recent PhD/MD in a relevant field or equivalent experience in field (Molecular Biology, Developmental Biology, Cell biology, Biochemistry, etc.)

 

Preferred Qualifications

A variety of different backgrounds could lead to success in this project, and expertise in one or more of the following would provide a foundation on which to receive additional training in the others:

  • disease modeling in NPCs/human neurons
  • iPS cells/ stem cell
  • cell biology/biochemistry/Molecular biology

 

Benefits

This position is eligible for full-time benefits.

 

Applicant Special Instructions

To apply for this position, please send a cover letter, CV, and contact information for three references to Bruno Benitez babenitez@wustl.edu

Information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs.

 

EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Postdoctoral Research Associate

The NeuroGenomics and Informatic (NGI) group at Washington University School of Medicine is recruiting multiple Postdoctoral Research Scientist.

The NGI generates and analyzes high-throughput multi-omic data to study neurodegeneration and diseases of the central nervous system with emphasis on Alzheimer’s disease, Parkinson’s disease, and other dementias. The ultimate goal of the NGI is to understand the biology of these diseases, to define novel biomarkers, and to identify novel therapeutical targets. Washington University School of Medicine is renowned for its research cohorts of neurodegenerative disorders, which include clinical, neuroimaging, and fluid biomarker phenotypes. We have pioneered in the employment of whole genome sequencing, genetic analyses of traditional cerebrospinal fluid (CSF) biomarkers and Mendelian Randomization approaches to identify the genetic architecture of neurodegeneration. We are currently employing deep molecular profiling of brain, CSF and plasma, including single-nuclei RNA-seq and proteomics assay, to characterize a large collection of well-characterized samples.  We are seeking for motivated researcher with strong analytical skills to join our effort and generate novel insights of neurodegeneration with this unique dataset, while working in a highly dynamic multidisciplinary and collaborative environment.  The new postdoctoral fellow/s will join a large team, currently twenty members, which is led by three faculty members and three senior scientists.

In addition to postdoctoral position, we have open position for (senior) staff scientists.  

Dr. Cruchaga and Dr. Harari are well funded with several grants from the National Institute of Ageing, the CZI and ongoing collaboration with the pharma industry. Our current research projects include the analyses of:

  • GWAS and whole genome sequencing of Neurodegenerative (ND) Cerebrospinal fluid (CSF) biomarkers (Amyloid beta, tau, TREM2, NFL, YKL40 and SNAP25),
  • Identification of rare genetic variants in large family-related and unrelated Neurodegenerative sequencing studies
  • Plasma, CSF and Brain Proteomic analysis using Mendelian Randomization
  • Brain transcriptomic analysis (Bulk RNA-seq/Deconvolution and single-nuclei RNA-seq)
  • Liquid biopsy (cell-free DNA/RNA as biomarkers for ND)
  • Identification of shared genetic architecture among ND traits (Alzheimer’s, Parkinson and FTD)

For further details please see our website: http://ngi.wustl.edu

Requirements

The successful applicant will hold, or shortly expects to obtain, a PhD qualification in Genetics, Bioinformatics, Computer science, Data science, Statistical Genomics or a related discipline involving the interrogation of ‘omics’ datasets.  A hands-on experience with large-scale human genomic or other omics (preferably related to neurodegeneration) studies is expected. He/she would have solid skills in at least one programming language (R, python or perl) and experience working in Linux and/or high-performance cluster environments. A strong ability to perform analytical reasoning to extract biological insights from data-driven approaches will be critical. In addition, familiarity to interrogate publicly available resources will be highly beneficial.

We offer competitive salaries and benefits, please refer to the Human Resources website (http://hr.wustl.edu), and Information on being a postdoc at Washington University in St. Louis can be found at http://postdoc.wustl.edu/prospective-postdocs.

Interested candidates should send a cover letter, an a copy of the CV to :Carlos Cruchaga (ccruchaga@wustl.edu) or Oscar Harari (harario@wustl.edu)

Diversity and Inclusion are core values at Washington University. Washington University seeks an exceptionally qualified and diverse faculty, staff, students and postdocs; women, minorities, protected veterans, and candidates with disabilities are strongly encouraged to apply. 

Scientist

The NeuroGenomics and Informatic group (https://neurogenomics.wustl.edu/) at Washignton University is seeking applicants for a Senior Scientist positions to work with highly dimensional data including RNA_seq, whole-genome, exome sequencing, GWAS, exome-chip, and quantitative phenotypes.

The goal is to identify novel variants and genes implicated in complex traits including Alzheimer’s disease, Parkinson’s disease and stroke using novel and integrative computational and statistical analyses.

The candidate will hold a PhD in statistics, Bioinformatics, Computational Biology, Biostatistics, Statistical Genetics, Medical Statistics, Mathematics or similar. The candidate should have a strong background in second-generation sequencing analyses (DNA and RNA), GWAS analyses (PLINK and SKAT-O), and multivariate and mixed model analyses. A working knowledge of UNIX, Perl/Python and R are also required.

This person will work directly with the PIs on the design, implementation, analyses and report of the research. She/he will also prepare and optimize analyses pipelines (scripts) for WES, WGS and RNA-seq. As well as analyze the sequence data including QC, and perform analyses.

She/he will join a team of six computational and statistical researchers working in bioinformatics, statistical genomics and genetics. The team is based in the laboratory of Drs. Carlos Cruchaga, and Oscar Harari which comprises over 16 people dedicated to understanding the architecture of neurodegenerative diseases.

Job Type: Full-time