Welcome to the NeuroGenomics and Informatics (NGI) Center
The NeuroGenomics and Informatics Center is a multidisciplinary team working at the forefront of personalized medicine.
The goal of the NeuroGenomics and Informatics Center is to understand the biology of neurodegeneration by using high-dimensional omic data and functional genomic approaches.
We leverage these approaches to identify novel genetic variants, genes and pathways implicated in disease, and new molecular biomarkers and therapeutic targets.
News
Workshop: Application of Machine Learning Tools to Omics in Neuroscience
The NGI will be hosting a Workshop on the “Application of Machine Learning Tools to Omics in Neuroscience” on February 18, 2021. This full-day, virtual event will feature basic introductory sessions on Machine Learning, plenary lectures by invited speakers, oral presentations of submitted abstracts, and a round table discussion. Everyone is invited to register by […]
MS4A4A is the major regulator of TREM2 levels
Drs. Harari, Benitez, Karch and Cruchaga leveraged biospecimens obtained from large and well-characterized human cohorts to identify a novel protective gene for Alzheimer disease, MS4A4A, that is also the major regulator of TREM2. This study provides a strong evidence of a biological link between TREM2 and MS4A4A in microglia in the context of AD. However, […]
Drs. Cruchaga and Karch receive new funding to advance personalized medicine in Alzheimer Disease
Drs. Cruchaga and Karch are some of the Washington University investigators that received funding from Centene to perform molecular phenotyping of Alzheimer’s cases to identify novel molecular biomarkers and the identification of novel therapeutically targets. Specifically we plan to develop a personalized medicine approach to understand the effects of Alzheimer’s disease risk genes by combining […]