We are always looking for creative, enthusiastic, and productive people who would like to work in an exciting, highly collaborative research environment.

Open Positions

Research Track Faculty Position in Human Statistical Genetics
Description
The Neurogenomics and Informatics Center (NGI), together with the Departments of Neurology, Genetics, and Psychiatry at Washington University School of Medicine is seeking an individual with experience in human statistical genetics. 
The newly formed Neurogenomics and Informatics Center (NGI) is seeking exceptional PhD, MD/PhD, or MD faculty candidates in basic and/or translational genomics or computational biology with a focus in neurodegeneration. The candidate will provide scientific and project managerial oversight for large-scale, multi-omic research projects. The ideal candidate will have strong expertise in GWAS, WGS, and RNA-seq analyses, and human statistical genetics.
 
The successful candidate will become integrated into the university’s neuroscience and genetics communities that feature highly successful members, a collaborative atmosphere, and broad research interests. The NGI is associated with several highly ranked graduate programs. The candidate will enjoy access to the NGI’s shared equipment, data, biospecimens, and expertise, as well as to specialized centers and state-of-the-art cores throughout the school of medicine.
 
The candidate will join a team of nine computational and statistical researchers working in bioinformatics, and statistical genomics and genetics. The complete team comprises over 20 people dedicated to understanding the architecture of neurodegenerative diseases.

Track
Research
 
Rank 
Commensurate with experience.
Required Qualification
This position is a research track faculty appointment at a rank commensurate with academic experience and qualifications.
The candidate will hold a PhD in statistics, bioinformatics, computational biology, biostatistics, statistical genetics, medical statistics, mathematics, or similar. The candidate should have a strong background in GWAS (PLINK and SKAT-O), WES/WGS (BWA, GATK), or RNA-seq analyses (STAR, SALMON, KALLISTO, DESEQ2). A working knowledge of UNIX, Perl/Python, R, and Docker are also required.
Department Name/Job Location
This position is the NeuroGenomics and Informatics group (Department of Psychiatry) at Washington University.
Applicant Special Instructions
Applicants should submit a CV, ½ page description of their single-most important paper to date highlighting the novelty of the findings (accepted, published, or BioRxiv deposited papers only), 2-page research statement, and the names/contact information of 3 references. 
Please send all requested material in one single PDF to Adam Suhy, (asuhy@wustl.edu). 
Disclosures and Benefits
Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Benefits
This position is eligible for full-time benefits.  Please click the following link to view a summary of benefits: https://hr.wustl.edu/benefits/.
EOE Statement
Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.
Postdoctoral Position in Alzheimer Disease: Multi-omics

Description

The NeuroGenomics and Informatics Center (NGI) at Washington University School of Medicine is recruiting multiple Postdoctoral Research Scientists. The NGI generates and analyzes Whole-Genome Sequencing data and high-throughput, multi-dimensional -omic data to study neurodegeneration and diseases of the central nervous system, with an emphasis on Alzheimer disease, Parkinson’s disease, and other dementias. The ultimate goal of the NGI is to understand the biology of these diseases, to define novel biomarkers, and to identify novel therapeutic targets. The Washington University School of Medicine is renowned for its research cohorts of neurodegenerative disorders, which include clinical, neuroimaging, and fluid biomarker phenotypes.

We have pioneered the use of whole-exome sequencing (WES) and whole-genome sequencing (WGS) data in familial (Cruchaga et al., Nature 2013., Fernandez et al., Eur J HumGenet 2016, Fernandez et al., PLoS Genetics 2017, Fernandez et al., Front Neuroscience 2018) and sporadic (Jin et al., Alzheimer Res Ther 2012, Benitez et al., PLoS Genetics, 2013, Benitez et al., N Engl J Med 2013 Jin SC Human Mol Genet 2014) Alzheimer disease to identify novel variants and genes associated with disease risk.

We have recently received several NIH R01 awards to generate and analyze large WGS datasets for both familial Alzheimer Disease and sporadic early-onset cases. We are seeking highly motivated researchers with strong analytical skills, especially in genetics and WGS/WES analyses to lead the analyses for these projects. The new postdoc(s) will join a large team, currently 30+ members, which is led by three faculty members, four postdocs, several PhD students, and three senior scientists.

Required Qualifications

    A successful applicant will have:

  • A PhD in Genetics, Bioinformatics, Computer Science, Data Science, Statistical Genomics, or a related discipline involving the interrogation of ‘omics’ datasets, or expect to obtain a degree in the near future,

  • Hands-on experience using PLINK, SKAT, BWA, and/or GATK with large-scale human genomic or other omics (preferably related to neurodegeneration) studies,
  • Solid skills in at least one programming language (R, python, or perl) and experience working in Linux and/or high-performance cluster environments,
  • A strong ability to perform analytical reasoning to extract biological insights from data-driven approaches,
  • Familiarity with interrogation of publicly available resources (highly beneficial).

Department Name/Job Location

This position is the NeuroGenomics and Informatics group (Department of Psychiatry) at Washington University.

Benefits

This position is eligible for full-time benefits.  Please click the following link to view a summary of benefits: https://hr.wustl.edu/benefits/.

Applicant Special Instructions

Interested candidates should send their cover letter and CV to Dr. Cruchaga (cruchagac@wustl.edu )

EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Fulfilled Positions

Project Manager

The goal of the Neurogenomics and Informatics group is a multidisciplinary team working at the forefront of personalized medicine. The goal of the NeuroGenomics and Informatics Group is to understand the biology of neurodegeneration by using high-dimensional omic data and functional genomic approaches. The Neurogenomics and Informatics group is looking for an experienced project manager to work directly with the center director. The project manager will be responsible for the oversight and administration of multiple research projects progress report and manuscript writing, and publication, coordination of the activities of a multidisciplinary team, or interfaces with multiple levels of the organization and external entities to ongoing and future projects

PRINCIPAL DUTIES & RESPONSIBILITIES:

Essential Functions:

  1. Holds responsibility for day-to-day activities of the Neurogenomics and Informatic center.
  2. Assists with drafting, writing, editing, and galley-proofing of progress report abstracts and article for publication
  1. Composes annual report for the center, maintain content for the center website and social media
  2. Supervises support staff and advises senior faculty in personnel management or internal policy.
  3. May prepare and maintain minutes from meetings, formal voting procedures, and committee activity related to proposals, ensuring follow up on decisions made.
  4. Provides planning and coordination of meetings and schedules various events and/or training.
  5. Establishes/enhances various contacts’, and contact with other centers and research groups to facilitate collaboration and exchange of information.
  6. Participates in project review meetings and report preparation and analysis.

CRITICAL SKILLS/EXPERTISE

  • Excellent administrative skills.
  • Experience with research required
  • Applicant should have significant experience with word processing, spreadsheets, graphics, and the applicant must have database and internet experience.
  • Excellent oral and written communication is required.
  • Applicant must be able to work independently and manage multiple assignments with various levels of priority.
  • Attention to detail and accuracy are essential

Department Name/Job Location

This position is the NeuroGenomics and Informatics group (Department of Psychiatry) at Washington University.

Benefits

This position is eligible for full-time benefits. Please click the following link to view a summary of benefits: https://hr.wustl.edu/benefits/.

Applicant Special Instructions

Interested candidates should send their cover letter and CV to Drs. Cruchaga (cruchagac@wustl.edu )

EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Research Laboratory Supervisor

The Neurogenomics and Informatics Center uses high throughput multi-omic approaches to understand the biology of neurodegeneration with emphasis in Alzheimer and Parkinson Disease. The Neurogenomics and Informatics Center a quickly growing group looking for an experienced laboratory supervisor that can work diligently in a team environment.

PRINCIPLE DUTIES & RESPONSIBILITIES:

Essential Functions:

  1. Performs laboratory administrative functions such as scheduling, purchasing and establishing record keeping systems.
  2. Supervises laboratory staff assigned, assuring appropriate study procedures, review of staff work, explaining policies and procedures and screening of new employees.
  3. Develops procedure manuals and operational/technical guidelines for lab studies.
  4. Participates in lab study processes, maintaining records and preparing reports as required.
  5. Researches and recommends new methods and procedures to maintain current capabilities, quality and standards following CAP and Part11 rules.

Department Name/Job Location

This position is the NeuroGenomics and Informatics group (Department of Psychiatry) at Washington University.

Benefits

This position is eligible for full-time benefits. Please click the following link to view a summary of benefits: https://hr.wustl.edu/benefits/.

Applicant Special Instructions

Interested candidates should send their cover letter and CV to Drs. Cruchaga (cruchagac@wustl.edu )

EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Bioinformatician: WGS and GWAS

The NeuroGenetics and Informatics (NGI) group (https://neurogenomics.wustl.edu/) at Washington University School of Medicine is recruiting a Bioinformatics Research Analyst to work in Dr. Cruchaga lab at the Washington University School of Medicine. The NGI generates and analyzes Whole-Genome Sequencing data and high-throughput multi-dimensional omic data to study neurodegeneration and diseases of the central nervous system with emphasis on Alzheimer’s disease, Parkinson’s disease, and other dementias. The goal of our research is to use genomic and multi-omic approaches to understand the biology of Alzheimer’s Disease, Parkinson Disease and other neurodegenerative disease. Our labs have pioneered the use of biomarker levels for Alzheimer and Parkinson disease as endophenotypes for genetic studies.

We are looking for a Bioinformatics Research Analyst with expertise in GWAS, WES/WGS and/or RNA-seq data analyses to work in a project focus on the identification of genes dysregulated in Alzheimer disease.

She/he will join a team of nine computational and statistical researchers working in bioinformatics, statistical genomics and genetics. The team comprises over 20 people dedicated to understanding the architecture of neurodegenerative diseases.

Required Qualifications

The candidate will hold a master in statistics, Bioinformatics, Computational Biology, Biostatistics, Statistical Genetics, Medical Statistics, Mathematics or similar. The candidate should have a strong background in GWAS (PLINK and SKAT-O), and WES/WGS (BWA, GATK) or RNA-seq analyses (STAR, SALMON, KALLISTO, DESEQ2). A working knowledge of UNIX, Perl/Python, R and Docker are also required.

Department Name/Job Location

This position is the NeuroGenomics and Informatics group (Department of Psychiatry) at Washington University.

Benefits

This position is eligible for full-time benefits. Please click the following link to view a summary of benefits: https://hr.wustl.edu/benefits/.

Applicant Special Instructions

Interested candidates should send their cover letter and CV to Dr. Cruchaga (cruchagac@wustl.edu )

EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.