Gabor Egervari, MD, PhD

I am interested in exploring the emerging interface between cellular metabolism and epigenetic mechanisms. Recent evidence suggests that transcriptional regulation is tightly linked with intermediary metabolism via the availability of substrates and co-factors for epigenetic enzymes. In addition, metabolic enzymes are recruited to the nucleus and chromatin to control local levels of specific metabolites. I am particularly interested in the role of the epigenetic-metabolic axis in the brain during learning and memory, with emphasis on alcohol use disorder and Alzheimer’s disease.